Original Berserk is worth watching, as is Neon Genesis Evangelion.
I enjoyed City Hunter more then I suspected, even if the pervert elements have not aged well.
Jojo's Bizarre Adventures is of course, a work of profound homoerotic genius.
Tehknolyze is the best cyberpunk/nihilistic anime and I will fight you on this
There is the usual Full Metal Alchemist to mention. Death Note is excellent for normies. I enjoyed Knights of Cydonia as proper space opera.
I find movies are more watchable sometimes, Anime is an inherently aesthethic medium so burning 200k on animation in 1.5 hours is the ideal.
Ghost in the Shell, Jinro the Wolf Brigade and Nausicaa and the Valley of the Wind are all terrific stuff.
Someday Legend of the Galactic Heroes becomes feasible, but not this day.